Among them, SαV‐C‐NVs are designed to block CD47‐SIPRα pathway to improve the sensitivity of phagocytes, M1‐NVs are used to repolarize M2‐to‐M1 TAMs, and P‐NVs are mainly employed to enhance affinity to post‐surgical tumor bed, as well as circulating tumor cells (CTCs) (Figure 9C). The gene discussed is CD47; the disease is neoplasm.