It often displays as unity of two or more opposites, such as Th1/Th2/Th17/Treg paradigm of CD4+ T cells or M1/M2 polarization of macrophages.[93] Many diseases, including autoimmune diseases, infectious diseases, inflammation, cancer, vascular diseases, and nerves system diseases, are accompanied with deviation of the existing balance. This evidence concerns the gene CD4 and cancer.