Currently, SGLT2 inhibitors (empagliflozin, canagliflozin, dapagliflozin, ertugliflozin) are recommended to reduce the risk of HF hospitalization in T2DM patients with either established cardiovascular disease or at high cardiovascular risk Moreover, the recently published European Cardiology Society (ESC) 2021 guidelines have given a Class I recommendation for dapagliflozin and empagliflozin for the treatment of HFrEF, with or without T2DM [50]. This evidence concerns the gene SLC5A2 and hydrops fetalis.