As aldehydes are the glycation components, it has been investigated whether the genes aldehyde dehydrogenase 2 (ALDH2) and 1B type alcohol dehydrogenase (ADH1B) are involved in the biosynthesis of CML and CEL with some evidence of a genetic polymorphism in CML metabolism (Nomi et al. 2020). Here, ALDH2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.