Following the steps of the metastatic cascade, integrins like ITGB4, which was highly expressed in Fra-2 overexpressing scid tumours, are also O-glycosylated and are suspected to influence the attachment of tumour cells to the ECM as well as cell-to-cell interactions (Oliveira-Ferrer et al. 2017). This evidence concerns the gene ITGB4 and neoplasm.