In both groups (Fra-2 cl 1 and cl 2), some interesting genes could be identified, e.g., in the Fra-2 cl 1 primary tumours LGALS1, ADRM1, and CTTN, which were upregulated and LUM (Lumican), MAN1A1, and SPARC, which were significantly downregulated. This evidence concerns the gene LUM and neoplasm.