However, our studies also demonstrate that the transcription factor Fra-2 is able to control the expression of other adhesion molecules as well (L1-CAM, ICAM-1, CD44, ITGB4, and TSPAN8) and thus allows the tumour cells to adhere to the selectin-deficient endothelium via these adhesion molecules. The gene discussed is TSPAN8; the disease is neoplasm.