Galectin-1 has been observed to arbitrate the adhesion of cancer cells to the ECM; laminin, fibronectin, and other glycoproteins presented in the basement membrane provide the necessary epitopes for Galectin-1-cell-ECM cross-linking (Cousin and Cloninger 2016; Jeschke et al. 2006; Brule et al. 1995). The gene discussed is LGALS1; the disease is cancer.