L1CAM and neoplasm: Supporting our former in vitro study (Schroder et al. 2010), we found a higher mRNA expression of the immunoglobulin superfamily cell-adhesion molecule L1-CAM in isolated Fra-2 cl 1 scid primary tumours, which could be confirmed by Western blot (Fig. 2a) and IHC analysis including primary tumour sections and metastasized cells in the lungs (Fig. 3a).