CD44 is a cell-surface glycoprotein with a postulated role in cancer metastasis (Marhaba and Zoller 2004) with binding domains for hyaluronan and other glycosaminoglycans, collagen, laminin, and fibronectin, all components of the ECM (Herrera-Gayol and Jothy 1999). The gene discussed is LAMB2; the disease is cancer.