The recent PROVE-HF study demonstrated that the reduction in NT-proBNP following sacubitril/valsartan treatment was associated with reductions in left atrial volume index, and ratio of early transmitral Doppler velocity/early diastolic annular velocity (E/e’), which reflect improvements in elevated cardiac filling pressures and are important prognostic factors in patients with HF [17]. Here, NPPB is linked to hydrops fetalis.