For aCL IgG and IgM, they found a higher positivity in the males.33With regard to APS incidence, Garcia et al, in a population study with adults, determined that the APS incidence was identical in both genders and more prevalent in the population over 75 years.11Manukyan et al, in a study performed in Germany and involving 5,000 individuals, found a strong association between the aCL and aβ2GPI IgM increased titers and age. The gene discussed is CD40LG; the disease is autoimmune polyendocrinopathy.