BRD4 and adenoviridae infectious disease: Previous studies suggest that Brd4 may directly inhibit lentiviral transcription based on interactions with viral specific components.(55, 56) Links between acetylation and viral transcription are evident from studies showing that inhibition of histone deacetylases (which increases genomic chromatin acetylation) enhances the oncolytic effects of adenovirus infection.(57, 58, 59) While the latter appears to occur through transcription and not transduction‐based mechanisms,(60) the complexity of adenoviral oncolysis does not permit a straightforward mechanistic comparison with our current work.