To establish more precise cause‐and‐effect relationships, we opted for siRNA‐mediated Brd4 depletion rather than Brd4 blockade using BET inhibitors such as +JQ1, as these inhibitors also target other BET family members (eg, Brd2 and Brd3).(48) Similar to induction of adenoviral GFP and Cre (Fig. 2), Brd4 depletion significantly enhances transcription of adenoviral BMP2 at 100 and 1000 multiplicity of infection (MOI) 2 days after siRNA transfection and adenoviral BMP2 transduction (Fig. 4A). The gene discussed is BRD3; the disease is infection.