FGF23 and sarcopenia: FGF23 binds to its receptor FGFR1c and co‐receptor αKlotho on the basolateral membrane.(105) The Klotho gene derived its name from the Greek fate who spun the thread of life because loss of the protein results in premature aging with shortened life span, sarcopenia, bone loss, and vascular calcification.(106, 107, 108) αKlotho is a single‐pass transmembrane protein that helps to stabilize FGF23 binding to FGFRs.