Moreover, due to the Dicer1 deletion, lower levels of Shwachman‐Bodian Diamond syndrome (SBDS) ribosome maturation factor were expressed in the osteoprogenitors, and when the Sbds gene was deleted from osteoprogenitors through Osx‐Cre in a subsequent experiment, it again resulted in a myelodysplasia, confirming the role of this signaling pathway in the disease pathogenesis. This evidence concerns the gene SBDS and Myelodysplasia.