TNF and acute myeloid leukemia: The endosteal vascular niche is remodeled in a murine model of AML by leukemia cell‐secreted anti‐angiogenic and inflammatory cytokines including TNF and CXCL2.(38) Together, these impair the ability to sustain normal hematopoiesis as the endosteal niche loses cells that support normal HSC maintenance, due to damage to stromal cells, ECs, and OBs.