In the current study, the GSEA results showed that high GJA1 expression was positively correlated with the hallmark gene sets EPITHELIAL_MESENCHYMAL_ TRANSITION and TGF_BETA_SIGNALING as well as several other tumor-related gene sets, providing further evidence that GJA1 is closely associated with tumor progression in HCCs. This evidence concerns the gene GJA1 and neoplasm.