The eleven active components of Prunella vulgaris L for diabetes combined with hypertension include steroids, flavonoids, etc., 41 key targets IL-6, NOS3, etc., and 21 significant signaling pathways, such as AGE-RAGE, HIF-1, etc., and analyzed the specific role of these targets and signaling pathways. This evidence concerns the gene RENBP and hypertensive disorder.