Strikingly, a recent investigation by Hou et al. found six deleterious variants such as p. Val 160Met, p. Gly181Arg, p. Arg240Cys, p. Pro335Leu, p. Gly432Ala, and p. Arg435Tyr in the TMPRSS2 gene, which are demonstrated as somatic mutations in different cancer databases and also suggest explanations for genetic susceptibility to COVID-19 [11]. This evidence concerns the gene TMPRSS2 and cancer.