TLR4 and mastitis: Lipopolysaccharide binding protein (LBP), antigen recognition receptor (CD14), tumor necrosis factor -α (TNF-α) and Interleukin-1β (IL-1β) in milk and blood of dairy cow mastitis were up-regulated, the expression levels of toll like receptor 4 (TLR4), p38 protein kinase and phosphorylated p38 protein (p-p38) induced by inflammation in udder were significantly increased, suggesting that the phosphorylation of related proteins in MAPK signaling pathway may be an important factor in the occurrence of mastitis (36).