Multivariate analysis, after adjusting for age and gender for all RA patients, revealed that PCSK9 was positively correlated with the presence of atheromatic plaques (p = 0.033), as well as IMT in the RCCA (p = 0.013) and a trend was observed for the LCCA (p = 0.060). This evidence concerns the gene PCSK9 and rheumatoid arthritis.