As renal diseases are closely related with cardiovascular health, our data raised new possibility that LPG-like nephropathy might be an important contributory factor for the onset and progression of atherosclerotic cardiovascular disease and premature death in Srb1/Apoe-/- and Srb1/Ldlr-/- mice, which were neglected previously. Here, APOE is linked to lipoprotein glomerulopathy.