Evidently, miRNAs and lncRNAs in EVs are associated with atherosclerosis, including miRNA-21, miRNA-150, miRNA-155, miRNA-126, miRNA-210, miRNA-505, miRNA-146a, miR-133, miRNA-223, miRNA-125, miRNA-let7, RNCR3, MALAT1, GAS5, and HIF1A-AS1 which provide a strong basis for their application as diagnostic markers for atherosclerosis. The gene discussed is MALAT1; the disease is atherosclerosis.