MAP2K4 and atherosclerosis: EVs secreted by BMSCs from aorta tissues of ApoE(-/-) atherosclerosis mice models were shown to contain significantly elevated miRNA-125b-5p levels, which induced the suppression of mitogen-activated protein 4 kinase 4 (Map4k4), down-regulated MMP-9 expression, inflammation, blood lipid accumulation and plaque size, as well as increased α-SMA expression, thereby alleviating apoptosis in atherosclerosis mice (64).