There were significant differences among the four groups in terms of age, body mass index, duration of diabetes, prevalence of hypertension, previous MI, previous stroke, LVEF, clinical presentation, triglycerides, estimated glomerular filtration rate, SYNTAX score, SYNTAX II score, and use of β-blocker, ACE inhibitor/angiotensin receptor blocker, and insulin (all P < 0.05). The gene discussed is ACE; the disease is Stroke.