Hashad and colleagues reported that the heterozygous and minor homozygous genotypes (G/A and A/A) of TNF-α (–308 G/A) SNP were significantly different in AKI and non-AKI patients and both genotypes were an independent risk for AKI development in patients with severe sepsis (Hashad et al., 2017). This evidence concerns the gene TNF and acute kidney injury.