SPOCK1 and gallbladder cancer: As for SPOCK1, studies have proved SPOCK1 as an EMT-related marker that was closely correlated with tumorigenesis and invasiveness in gastric cancer (Yan et al., 2017; Chen et al., 2018), prostate cancer (Wang et al., 2016), pancreatic cancer (Li et al., 2020), gallbladder cancer (Shu et al., 2015), and lung cancer (Miao et al., 2013).