Then, by applying univariate and Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression analyses, we identified COL8A1, SPOCK1, AEBP1, and TIMP2 as prognostic CAF markers and constructed the four-gene CAF signature capable of predicting prognosis and therapeutic responses in GC. The gene discussed is AEBP1; the disease is gastric cancer.