Zhang et al. identified COL8A1 as the prognostic hub gene highly correlated with Wnt2, which is elevated selectively in CAFs, and high co-expression of COL8A1 and Wnt2 was an independent adverse prognostic factor for colon cancer patients (Katoh, 2001; Zhang et al., 2020). Here, WNT2 is linked to malignant colon neoplasm.