Vanins (Vnn) are enzymes that convert pantetheine to vitamin B5, and while absence of Vnn1 activity improved insulin sensitivity in high fat diet-fed animals, its short-term inhibition may have limited value as an anti-diabetic strategy (van Diepen et al., 2016), neurotrimin (Ntm) is a novel biomarker of heart failure (Cao et al., 2015). This evidence concerns the gene NTM and heart failure.