SLC5A1 and diabetes mellitus: When capsazepine blocked the TRPV1 ion channel, in the Cap+CPZ group, the mRNA and protein expression levels of SGLT1, GLUT2, and GLUT5 were significantly increased in the ilium of diabetic rats, indicating that capsaicin combined with capsazepine could lead to a more severe intestinal glycometabolism disorder in STZ-induced diabetic rats and further accelerate the progression of diabetes.