Consistent with the previous study, the results showed that ARP, EX, and ARP combined with EX during the HFD feeding could sufficiently attenuate the inflammatory response, including CRP, TNF-α, and IL-6, suggesting that the combination of ARP and EX exerted the beneficial effects on the obesity-induced inflammatory activity in obesity-induced mice. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.