Hif1a antisense oligonucleotide treatment was also associated with lower liver steatosis, increased hepatic Ppara expression, and decreased expression of the lipogenic genes Scd1 and acetyl-CoA carboxylase (48), though again it is unclear whether this was due to Hif1a interference in the liver or secondary to effects in other tissues. This evidence concerns the gene HIF1A and Hepatic steatosis.