PPARGC1A and metabolic dysfunction-associated steatotic liver disease: Hepatic Hif1α deletion in a mouse model of NAFLD (mice fed a choline deficient diet), however, led to lower Lipin1 mediated PPARα/PGC1α pathway activation, which worsened steatosis relative to wild type mice (41), suggesting HIF1α is required to maintain FAO in NAFLD.