Similarly, hepatocyte-specific deletion of Vhl, which increases both HIF1α and HIF2α signalling led to fibrosis which was normalised by Hif2a (but not Hif1a) deletion (34), and hepatocyte-specific deletion of Hif2a protects against fibrosis in mouse models of NAFLD (3). Here, VHL is linked to metabolic dysfunction-associated steatotic liver disease.