However, as demonstrated by the observation that lipogenic gene expression is decreased in mice with HIF2α activation due to Vhl disruption (32), while it is increased in NAFLD rodent models (9) [which also show HIF2α activation (3)], this does not necessarily mean that HIF2α in NAFLD also reduces FAO. The gene discussed is VHL; the disease is metabolic dysfunction-associated steatotic liver disease.