HIF1A and metabolic dysfunction-associated steatotic liver disease: Overall, evidence suggests that HIF-signalling is involved in HSC activation by acting directly in HSCs to increase expression of fibrogenic mediators, as well as by increasing the expression of signalling factors that activate HSCs in hepatocytes and Kupffer cells, though this has not been investigated in the context of NAFLD in vivo and the relative importance of HIF1 and HIF2 remains unclear.