It was highlighted, in 154 NAFLD adult Hong Kong residents, a PNPLA3 involvement in regulating the response to 30 min per day of physical exercise and an individually designed dietary regimen oriented to enhance the consumption of fruit, vegetables, moderate carbohydrates, low fat, low glycemic index, and low-caloric products, in accordance with the recommendations of the American Dietetic Association (34). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.