The main involvement of these genes in the hepatic fat accumulation could give the possible explanation for the associated insulin resistance that in turn represents one of the causes but also the effect of the hepatic steatosis and worsening fibrosis in NAFLD context as well as the linked systemic inflammation that typically affect this category of subjects determining higher TBARS and CRP levels (19, 37, 38). This evidence concerns the gene CRP and fibrosis.