The key words were “juvenile spondyloarthirtis”, “enthesitis-related arthritis (ERA)”, “pathophysiology”, “signal transduction”, “epigenetics”, “neuroendocrine pathways”, “stress response”, “HPA axis”, “sex hormones”, “gene expression”, “proteomics”, “Gut–joint axis”, “dysbiosis” “NLRP3”, “tissue hypoxia”, “new bone formation (NBF)” in combination with “macrophage migration inhibitory factor (MIF)”. The gene discussed is NLRP3; the disease is enthesitis-related juvenile idiopathic arthritis.