Similarly to AS, the anti-inflammatory and anti-migratory effects of miR-451 that resulted in suppression of MIF, IL-6, TNF-α or RANTES expression, have been described in vitro in dendritic cells and synovial fibroblasts of RA patients and in vivo in mice with collagen-induced arthritis (133, 134). This evidence concerns the gene MIF and rheumatoid arthritis.