RNASE3 and asthma: Serum MBD2 and MPO levels were higher in patients with Th17 severe asthma compared to patients with T2 severe asthma (P < 0.001; Figures 2A,C), but serum ECP levels were lower in patients with Th17 severe asthma compared to those with T2 severe asthma (P = 0.003; Figure 2B).