Studies have shown that MBD2 is significantly increased in neutrophilic severe asthma mouse models, it is positively correlated with IL-17A and it can regulate Th17 cell differentiation through its downstream molecules, such as transcription factor hypoxia-inducible factor 1α and suppressor of cytokine signaling 3 (13, 44). The gene discussed is SOCS3; the disease is asthma.