SPAM1 and neoplasm: Cho et al. (2018) loaded membrane protein signal regulatory protein α (SIRPα) into exosomes for antitumor treatment by blocking the CD47 receptor on tumor cells. In the study, they found that phagocytosis of tumor cells and inhibition of tumor growth were enhanced when compared with the case using ferritin nanocages as vehicles (Figures 2D,E). In another study, exosomes harboring PH20 hyaluronidase were developed to advance tumor penetration via hyaluronan degradation (Hong et al., 2018).