LRG1 and esophageal squamous cell carcinoma: Apoptosis effected by LRG1 was also shown in a study of human esophageal squamous cell carcinoma by a decrease in bcl-2 and increases in Bax and caspase 3 expression when LRG1 was overexpressed by LRG1 transfection and opposite levels as a consequence of LRG1 RNA silencing (Zhang et al., 2020).