RUNX transcription factors are key targets for activation by the TGF family (Ito and Miyazono, 2003) and synergy in cancer has been shown between EGFR and TGF-β1 (Uttamsingh et al., 2008) as well as between JAK/STAT3 and TGF-β1 (Liu et al., 2014). Here, TGFB1 is linked to cancer.