Smits et al. (2012) showed there is significant low-expression of miR-125b in ECs co-cultured with U87 glioblastoma line cells. Moreover, the authors demonstrated that miRNA-125b inhibits angiogenic processes by directly regulating Myc-associated zinc finger protein (MAZ)/VEGF signaling pathway expression. It is known that, MAZ-binding sites are located in the promoter regions of angiogenic factor VEGF. The gene discussed is VEGFA; the disease is glioblastoma.