Furthermore, the authors demonstrated that the transcription factor GATA binding protein 4 (GATA-4) is overexpressed in malignant meningioma, which in turn regulates Cyclin D1, and it negatively regulates the miR-497 expression with an increase in cell viability in vitro. Importantly, that a cell cycle protein cyclin D1 is an established cancer-driving protein (Montalto and De Amicis, 2020). This evidence concerns the gene CCND1 and meningioma.