Therefore, exosomes secreted by glioblastoma cells are enriched in mRNA, which enzymes of DNA repair as methylation of the O(6)-Methylguanine-DNA methyltransferase (MGMT) promoter and alkylpurine–DNA–N-glycosylase (APNG), and the transfer of these mRNAs into recipient cells can significantly increase the level of chemoresistance (Shao et al., 2015). The gene discussed is MGMT; the disease is glioblastoma.