Tumor-infiltrating NK cells’ function can also be dampened by NK cell-autonomous inhibitory checkpoints such as PD-1, TIGIT, CD96, TIM-3, LAG-3, CTLA-4, KIR2DL-1/2/3 and NKG2A (Guillerey et al., 2016). Here, HAVCR2 is linked to neoplasm.