CD4 and neoplasm: However, innate immune response [dendritic cells (DCs), natural killer (NK) cells, TAMs, and tumor-associated neutrophils (TANs)] and adaptive immune response [CD8+ cytotoxic T cells (CTLs), CD4+ T helper 1 (Th1), and B cells] are complementary and interdependent (Tanaka et al., 1999).