The dysregulation of synaptic pruning by astrocyte and complement protein responsive microglia has been implicated in SZ, bipolar disorder (BD), and stress- or drug-induced psychosis (Feinberg, 1982; Stevens et al., 2007; Eroglu and Barres, 2010; Paolicelli et al., 2011; Petanjek et al., 2011; Sellgren et al., 2019). Here, VTN is linked to bipolar disorder.