GFAP expression suggesting astrogliosis in chimpanzee brains does not appear to increase during aging as it does in humans suggesting lower levels of oxidative stress, and, while astrogliosis is observed in cortex layer I and the hippocampus of chimpanzees exhibiting AD pathology, it is not as widely spread throughout the cortex as has been observed in human postmortem AD tissues (Munger et al., 2020). Here, GFAP is linked to Alzheimer disease.