INSR and Focal cortical dysplasia: It has also been suggested that increased INSR and ITGB8 may be related to human-specific differences in mTOR signaling pathway activation in RGs, particularly oRGs, and mutations related to mTOR signaling have been linked to ASD, focal cortical dysplasia, and glioblastoma multiforme (Ceccarelli et al., 2016; Mora-Bermúdez et al., 2016; Pollen et al., 2019).