TBR1 and infection: For example, researchers infected human and chimpanzee cerebral organoids with the Brazilian Zika virus (ZIKVBR) and found a reduction in both TBR1+ and CTIP2+ cortical neurons, and a subsequent reduction in the size of the CP-like structure of human organoids following infection, but they did not observe these effects in chimpanzee organoids after ZIKVBR infection suggesting human-specific neurotropism adaptations of ZIKVBR (Cugola et al., 2016).