This issue may be addressed using temperature-sensitive variants that have been reported in several human diseases, including albinism and cystic fibrosis (King et al., 1991; Sharma et al., 2001; Wang et al., 2008), and decreased activity of otoferlin due to structural changes with rising temperatures may have an additive effect on the phenotype, as verified in previous reports (Strenzke et al., 2016). This evidence concerns the gene OTOF and cystic fibrosis.