Evidence of colocalization across variants nearby HMGCR proxying HMG-CoA reductase inhibition and ankylosing spondylitis with a posterior probability (PPA) > 0.01 was detected for three SNPs, rs7703051, rs11749783 and rs3846663, of which all are in strong linkage disequilibrium with each other (r2 = 1.0) (Supplementary Figure 4). Here, HMGCR is linked to ankylosing spondylitis.