AR and posterior cortical atrophy: By using the in vitro coculture system, Smith and colleagues found that immortalized human prostate myofibroblast cell line PShTert with AR activation could retard the cell growth of various PCa cells including PC3, Du145, C4-2B, and LNCaP cells, highlighting the protective role of AR in CAFs during PCa development (Palethorpe et al., 2018).