Another document strengthened this conclusion by pinpointing that loss of AR in CAFs led to the enhanced expression levels of interferon gamma (IFN-γ) and macrophage colony-stimulating factor (M-CSF), which acted on PCa cells and educated them to differentiate into cancer stem-like cells (Liao et al., 2017) characterized with more invasive properties. This evidence concerns the gene IFNG and posterior cortical atrophy.