Similarly, disruption of the AR/FlnA complex by drug-like compound Rh-2025u-stapled peptide, which was developed from the AR amino acid sequence required for the interaction with FlnA (Loy et al., 2003; Castoria et al., 2011), abolished the androgen-induced migration and invasiveness of CAFs, consequently leading to less recruitment of CAFs to PCa and suppressing PCa-CAF organoid growth (Di Donato et al., 2021). Here, AR is linked to posterior cortical atrophy.