Given the fact that androgen receptor (AR) plays central roles in PCa carcinogenesis (Heinlein and Chang, 2004; Lonergan and Tindall, 2011), androgen deprivation therapy (ADT) is the mainstream treatment for PCa, which is effective for 2–3 years before PCa progresses to castration-resistant PCa (CRPC; Ruizeveld de Winter et al., 1994; Henshall et al., 2001; Scher et al., 2004). The gene discussed is AR; the disease is posterior cortical atrophy.