Consistent with this report, HUVEC-enhanced cell invasion of PCa cells via downregulating the AR level was also observed by Jiang et al. AR reduction was promoted by the interaction of CCL5 on endothelial cells with its receptor CCR5 on PCa cells, triggering mitochondria-mediated autophagy, one mechanism responsible for cell invasion of PCa cells (Zhao et al., 2018). Here, AR is linked to posterior cortical atrophy.