Repression of glycolytic genes by Klf9 fits with its reported inhibition of growth and regeneration (Apara et al., 2017; Galvao et al., 2018) and regulation of stem-cell metabolism (Cvoro et al., 2015) and could also contribute to its role in tumor suppression (Sun et al., 2014; Zhong et al., 2018), given the reliance of cancer cells on glycolysis. This evidence concerns the gene KLF9 and cancer.