FKBP5 and obesity due to melanocortin 4 receptor deficiency: Elevated FKBP5 expression contributes to HPA dysfunction and associated diseases (Binder et al., 2004; Binder, 2009; Klengel et al., 2012; Li et al., 2020), including diabetes and obesity (Pereira et al., 2014; Pena et al., 2020).