CXCL12 (SDF-1α)/CXCR4 signaling is upregulated in radiation-induced EndoMT in tumor vasculature where it is required for tumor-associated macrophage recruitment (Choi et al., 2018), and knockdown of either of CXCL12’s receptors, CXCR4 and CXCR7, disrupts angiogenic sprouting in vitro (Hultgren et al., 2020). Here, CXCL12 is linked to neoplasm.