Through lasso regression analysis, we selected seven optimal RNA construction models, namely, AGAP3, NHSL1, ENOPH1, NRG1, SNHG16, hsa-mir-1271-5p, and hsa-mir-26b-5p, to predict the prognosis of patients with colon cancer (Figures 3A–C). This evidence concerns the gene AGAP3 and malignant colon neoplasm.