NOTCH1 and colorectal carcinoma: Transwell experiments were preformed to detect the migration of CRC, and the result showed that NOVA1 knockdown-mediated CRC cell migration inhibition could be reversed by SORBS2-exon3 downregulation (Figure 4E), which indicated that NOVA1/SORBS2-exon3/NOTCH1 was involved in the migration of CRC (Figure 4F).