Previous studies have shown that the WT1 gene is highly expressed in epithelial ovarian cancer tissues (Hylander et al., 2006), and can regulate the metastasis and invasion of ovarian cancer through the E-cadherin and ERK1/2 signaling pathways (Barbolina et al., 2008; Han et al., 2020). The gene discussed is MAPK3; the disease is ovarian carcinoma.