At the Urotensin II Receptor (UTS2R), the two endogenous orthosteric agonists, URP and urotensin II (UII), display different biased signaling profiles that may contribute to heart failure in distinct ways (Billard et al., 2019) with URP concentration being 10× higher than UTII in plasma of patients with acute heart failure (Jani et al., 2013). The gene discussed is UTS2R; the disease is heart failure.