PIK3CA and angioosteohypertrophic syndrome: Indeed, PIK3CA mutations have been described in 21 patients with Klippel–Trenaunay syndrome (KTS) (12), in capillary malformation of the lower lip, lymphatic malformations of the face and neck, asymmetry, and partial or generalized overgrowth (CLAPO) syndrome (13), and in diffuse capillary malformation with overgrowth (DCMO) (14).