The overexpression of the lncRNA DHRS4-AS1 is related to the inhibition of cancer stemness in NSCLC via abrogation of the expression of Sox2, Oct4, CD34, and CD133 through sponging of miR-224-3p and upregulation of the tumor suppressors TP53 and TET1 (25, 101, 106). This evidence concerns the gene SOX2 and non-small cell lung carcinoma.