Recent studies have revealed that the oncogenic lncRNAs AGAP2 Antisense RNA 1 (AGAP2-AS1) and ANRIL can promote tumor cell growth by repressing the expression of the suppressors Large Tumor Suppressor Kinase 2 (LATS2) (21), Kruppel Like Factor 2 (KLF2) (22), and p21 (63) via interacting with EZH2 in non-small cell lung cancer (NSCLC). This evidence concerns the gene KLF2 and neoplasm.