NRBP1 and colorectal carcinoma: In addition, NRBP1, which encodes multidomain putative adapter proteins (69), has an anti-tumor role against CRC tumorigenesis and progression, as an in vivo/in vitro study (70) showed that the higher expression of NRBP1 inhibited CRC cell proliferation and anti-apoptosis and correlated with better prognosis.