In agreement with high ranks between the 2 values in AA women, we detected 1 genetic and 6 lifestyle factors as the topmost predictive variables for CRC risk (Figures 1A, , B): PCSK1 rs9285019 and years as a regular smoker, percent calories from PFA/day, dietary total sugar intake, age at enrollment, age at menopause, and duration of OC use. The gene discussed is PCSK1; the disease is colorectal carcinoma.