METTL3 and hepatocellular carcinoma: Fourth, Chen et al. demonstrated that METTL3 overexpression markedly reduces RAD52 motif 1 (RDM1) mRNA expression via m6A modification; RDM1 knockdown increases HCC cell proliferation, colony formation and the cell population at the G2/M phase, as RDM1 serves as a tumor suppressor in HCC (76).