Depletion of METTL3 in mouse xenograft models increases sorafenib resistance in HCC by decreasing the stability of FOXO3 mRNA (without METTL3 depletion, METTL3 causes m6A modification of FOXO3 mRNA, increasing its stability via a YTHDF1-dependent mechanism) (105). Here, METTL3 is linked to hepatocellular carcinoma.