They ascribed the contradictory findings regarding the METTL14 expression pattern and role in HCC samples compared to normal samples to the heterogeneity of HCC cell lines and clinical samples, the versatility of the METTL3-METTL14 heterocomplex, and m6A-independent effects of METTL14. The gene discussed is METTL3; the disease is hepatocellular carcinoma.