The latter study found that YTHDF2 was downregulated in HCC by hypoxia-inducible factor (HIF)-2α, which reduced the degradation of m6A-containing interleukin 11 (IL11) and serpin family E member 2 (SERPINE2) mRNAs, leading to inflammation-mediated malignancy and disruption of vascular normalization (92). This evidence concerns the gene SERPINE2 and hepatocellular carcinoma.