CDH5 and neoplasm: Recently, we demonstrated that inhibition of the AM pathway induces phosphorylation of both VE-cadherin on Tyr731 (pVE-cadherinY731) and β-catenin on Ser33/Ser37/Thr41 through activation of the protein tyrosine kinase Src; inhibiting cell-cell contacts and therefore leading to an increase in endothelial cell permeability, vascular collapse and regression of tumor neo-vessels (13).