In an analysis conducted on a population of 37 cases of CHAs (26), the presence of IOL was seen to be common in patients with congenital hemolytic anemias, especially in those with PK deficiency and with congenital dyserythropoietic anemia type II (CDAII), who presented particularly high ferritin and transferrin saturation levels, even regardless of transfusion dependency. The gene discussed is TF; the disease is congenital dyserythropoietic anemia type 2.