NADH:ubiquinone oxidoreductase core subunit Fe-S protein 1 (NDUFS1) is very important to electron transfer, while altered NDUFS1 expression would lead to the decrease of mitochondrial membrane potential, the elevated production of reactive oxygen species, and corresponding tumor progression, migration, and epithelial-mesenchymal transition (33). The gene discussed is NDUFS1; the disease is neoplasm.