HIF1A and acute myeloid leukemia: (24) showed that bone marrow (BM) cells separated from AML patients without remission produce higher levels of HIF-1α and glucose transporter 1 (GLUT1), as well as hexokinase 2 (HK2) and lactate dehydrogenase (LDH), which are considered the main controlling stages of glycolytic flux, than those from patients with full or partial remission and healthy donors (31).