(24) showed that bone marrow (BM) cells separated from AML patients without remission produce higher levels of HIF-1α and glucose transporter 1 (GLUT1), as well as hexokinase 2 (HK2) and lactate dehydrogenase (LDH), which are considered the main controlling stages of glycolytic flux, than those from patients with full or partial remission and healthy donors (31). Here, HK2 is linked to acute myeloid leukemia.