Interestingly, strong nuclear expression of RXRα is also reported in epidermal keratinocytes of normal human skin and we reported for the first time that its expression is reduced or lost in skin keratinocytes adjacent to melanocytic tumors during melanoma progression in humans (33) suggesting a non-cell autonomous role of keratinocytic RXRα in suppressing melanoma progression. The gene discussed is RXRA; the disease is melanoma.