Similarly, BMI [normal, HR: 0.448 (0.207–0.969, P=0.041; overweight, HR: 0.393 (0.162–0.956), P=0.039], degree of tumor differentiation [HR: 1.667 (1.051–2.643), P=0.030], N stage [N1, HR: 2.792 (1.458–5.349), P=0.002; N2, HR: 6.133 (2.781–13.526), P<0.001], LMR [HR: 0.392 (0.205–0.748), P=0.005], and post-CEA level [HR: 3.072 (1.861–5.073), P<0.001] were significant independent variables associated with DFS (Supplementary Table S4). Here, CEACAM5 is linked to neoplasm.